Blar i forfatter "Ludvigsen, Maria A."

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    • The human polyomavirus KI: A study on cell permissivity, sub-cellular localization of VP1 and presence in cerebrospinal fluid and urine 

      Ludvigsen, Maria A. (Master thesis; Mastergradsoppgave, 2011-11-17)
      KI polyomavirus (KIPyV) is a relatively newly discovered human polyomavirus originally identified in respiratory tract samples. Little is known about the route of infection or transmission, and the pathogenic properties of this virus are virtually unknown. The life cycle of KIPyV has not been studied as a permissive cell system has not been identified so far. The bona fide sites of viral replication ...

    • Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation 

      Falquet, Mar; Prezioso, Carla; Ludvigsen, Maria A.; Bruun, Jack-Ansgar; Passerini, Sara; Sveinbjørnsson, Baldur; Pietropaolo, Valeria; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)
      Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive MCC cells is the expression of a C-terminal truncated LTag. Protein kinase A (PKA) plays a fundamental role in a variety of biological processes, ...